منابع مشابه
Teratogenic effects of antiepileptic drugs
The use of older generation antiepileptic drugs (AEDs) during pregnancy is known to be associated with a two- to threefold increased risk of birth defects in the offspring and possible also other adverse outcomes in the exposed infant. Much less has been known about newer generation AEDs in this respect. Recent studies based on national registries as well as specific epilepsy and pregnancy regi...
متن کاملTeratogenic mechanisms of medical drugs.
BACKGROUND Although prescription drug use is common during pregnancy, the human teratogenic risks are undetermined for more than 90% of drug treatments approved in the USA during the past decades. A particular birth defect may have its origins through multiple mechanisms and possible exposures, including medications. A specific pathogenic process may result in different outcomes depending upon ...
متن کاملUse of Anticonvulsants During Pregnancy: Teratogenic Risks
The chapter summarizes literature on the teratogenic effects of anticonvulsants and presents data from the Swedish Medical Birth Register. Many anticonvulsants have a teratogenic effect which varies between individual drugs with the highest risk associated with the use of valproic acid and probably topiramide. For some much used drugs like carbamazepine and lamotrigine the risk is not much elev...
متن کاملEpilepsy, risks and insurance
Improvements in the diagnostic and therapeutic approach to patients with epilepsy have substantially changed the outcome, and consequently, the socio-cultural implications of the disease. Up to 90% of patients from different countries have prolonged periods of seizure remission 1-3 and about 60% of those who have been taken off treatment remain seizure-free at two years 4. This brings a conside...
متن کاملMinimizing risks to drugs.
Sir, Pharmacovigilance is defined as science and activities relating to the detection, assessment, understanding and prevention of adverse effects or any other drug related problem. Over the past century, medicines and vaccines have transformed the practice of modern medicine contributing substantially to reduction in morbidity and increase in life expectancy. However medicines and vaccine use ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMJ
سال: 1999
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.318.7193.1289a